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. 1995 Jun;140(2):843-56.
doi: 10.1093/genetics/140.2.843.

Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent

J Dupuis  1 , P O Brown, D Siegmund
Affiliations

Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent

J Dupuis et al. Genetics. 1995 Jun.

Abstract

A multilocus model for complex traits is described that generalizes the additive and multiplicative models and hence allows simultaneously for both heterogeneity and gene interaction (epistasis). Statistical methods of linkage analysis are discussed under the assumption that identity by descent data from a dense set of polymorphic markers are available. Three methods, single locus search, simultaneous search and conditional search, are described and compared.

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