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Clinical Trial
. 1995 Aug;23(2):119-22.
doi: 10.1016/0168-8278(95)80324-6.

Failure of ursodeoxycholic acid to prevent acute cellular rejection after liver transplantation

G P Pageaux  1 , P Blanc, P F Perrigault, F Navarro, J M Fabre, B Souche, J Domergue, D Larrey, H Michel
Affiliations
Clinical Trial

Failure of ursodeoxycholic acid to prevent acute cellular rejection after liver transplantation

G P Pageaux et al. J Hepatol. 1995 Aug.

Abstract

Background/aims: Acute rejection is still a major problem after liver transplantation. Ursodeoxycholic acid has beneficial effects in cholestasis by reducing the expression of major histocompatibility complex antigens.

Methods: We have performed a double-blind randomised study comparing ursodeoxycholic acid with placebo for the prevention of acute cellular rejection after liver transplantation. Twenty-six patients received ursodeoxycholic acid 600 mg per day and 24 patients received placebo for 2 months.

Results: Neither rejection incidence nor rejection severity was significantly different in the two groups (p > 0.90).

Conclusions: We conclude that adjuvant ursodeoxycholic acid administration does not prevent rejection after liver transplantation.

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