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. 1978 Dec 8;26(3):199-202.
doi: 10.1007/BF02013258.

Effects of a single dose of fluoride on calcium metabolism

M J Larsen, F Melsen, L Mosekilde, M S Christensen

Effects of a single dose of fluoride on calcium metabolism

M J Larsen et al. Calcif Tissue Res. .

Abstract

Fluoride 27 mg was given perorally to 14 subjects. It was found that the serum fluoride concentration increased followed by a decrease to normal levels during 24 h. Serum concentrations of calcium and phosphate decreased initially whereas those of serum immunoreactive parathyroid hormone increased. After 24 h the measured quantities were within normal limits. The results are discussed with reference to mineralization of hard tissues and to fluoride treatment of osteoporotic patients.

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