Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978;1(4):229-31.
doi: 10.1007/BF00257155.

Pharmacokinetics of intravenous cyclophosphamide in man, estimated by gas-liquid chromatography

F D Juma, H J Rogers, J R Trounce, I D Bradbrook

Pharmacokinetics of intravenous cyclophosphamide in man, estimated by gas-liquid chromatography

F D Juma et al. Cancer Chemother Pharmacol. 1978.

Abstract

A simple gas chromatographic assay utilising alkali flame ionisation detection is described for the estimation of cyclophosphamide as its trifluoroacetate derivative from plasma. Examination of five patients following intravenous cyclophosphamide gave values of 8.9 h (SD 2.7) for the half-life and 0.061 liters/h/kg (SD 0.011) for whole-body clearance of the drug.

PubMed Disclaimer

References

    1. Cancer Res. 1977 Aug;37(8 Pt 1):2538-43 - PubMed
    1. Cancer Treat Rep. 1976 Apr;60(4):403-8 - PubMed
    1. J Pharm Sci. 1974 Oct;63(10):1554-8 - PubMed
    1. Br J Pharmacol. 1971 Nov;43(3):677-80 - PubMed
    1. Cancer Treat Rep. 1976 Apr;60(4):493-500 - PubMed

Substances