doi: 10.1126/science.270.5242.1681.
Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis
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- PMID: 7502081
- DOI: 10.1126/science.270.5242.1681
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Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis
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Abstract
Pineal serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, or AA-NAT) generates the large circadian rhythm in melatonin, the hormone that coordinates daily and seasonal physiology in some mammals. Complementary DNA encoding ovine AA-NAT was cloned. The abundance of AA-NAT messenger RNA (mRNA) during the day was high in the ovine pineal gland and somewhat lower in retina. AA-NAT mRNA was found unexpectedly in the pituitary gland and in some brain regions. The night-to-day ratio of ovine pineal AA-NAT mRNA is less than 2. In contrast, the ratio exceeds 150 in rats. AA-NAT represents a family within a large superfamily of acetyltransferases.
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