T cell responses in macaques after vaginal immunization with particulate SIV p27 antigen
Affiliations
- PMID: 7502859
Item in Clipboard
T cell responses in macaques after vaginal immunization with particulate SIV p27 antigen
Adv Exp Med Biol.
1995.
Abstract
Rhesus monkeys were immunized by the vaginal and oral routes using a recombinant particulate simian immunodeficiency virus (SIV) antigen. Augmenting vaginal by oral immunization in macaques elicits proliferative CD4+ T cells in the circulation which are specific to the immunizing p27 antigen. Reconstitution of enriched CD4+ T cells, B cells and macrophages from circulating mononuclear cells help B cells in specific IgA anti-p27 antibody synthesis. The results suggest that augmented vaginal immunization induces systemic CD4+ T and B cell responses which may play a part in the protective immunity against SIV (HIV) infection.
Similar articles
-
Induction of IgA and IgG antibodies in vaginal fluid, serum and saliva following immunization of genital and gut associated lymphoid tissue.Adv Exp Med Biol. 1995;371B:1567-73. Adv Exp Med Biol. 1995. PMID: 7502858
-
T- and B-cell functions and epitope expression in nonhuman primates immunized with simian immunodeficiency virus antigen by the rectal route.Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8638-42. doi: 10.1073/pnas.90.18.8638. Proc Natl Acad Sci U S A. 1993. PMID: 7690967 Free PMC article.
-
Genital-associated lymphoid tissue in female non-human primates.Adv Exp Med Biol. 1995;371A:357-65. doi: 10.1007/978-1-4615-1941-6_75. Adv Exp Med Biol. 1995. PMID: 8525944
-
Anti-HIV and -SIV immunity in the vagina.Int Rev Immunol. 2003 Jan-Feb;22(1):65-76. doi: 10.1080/08830180305230. Int Rev Immunol. 2003. PMID: 12710504 Review.
-
Innate immunity and HIV-1 infection.Adv Dent Res. 2011 Apr;23(1):19-22. doi: 10.1177/0022034511399081. Adv Dent Res. 2011. PMID: 21441475 Review.
MeSH terms
Substances
LinkOut - more resources
Medical
Research Materials
Miscellaneous