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. 1978 Aug;35(2):391-5.

Stimulation of human peripheral blood lymphocytes by Tamm-Horsfall urinary glycoprotein

J S Hunt, A R McGiven

Stimulation of human peripheral blood lymphocytes by Tamm-Horsfall urinary glycoprotein

J S Hunt et al. Immunology. 1978 Aug.

Abstract

Tamm-Horsfall urinary glycoprotein (THP), prepared by salt precipitation of pooled urine from normal individuals, stimulated purified human peripheral blood lymphocytes (PBL) to undergo blastoid transformation. the response was measured by tritiated thymidine uptake into DNA after 6 days in culture. Several batches of THP stimulated, in varying degrees, all samples of PBL tested and the response approached that seen with the mitogens phytohaemagglutinin (PHA), Concanavalin A (Con A) and pokeweed mitogen (PWM) after 4 days in culture. The response usually exceeded that seen after 6 days with tuberculin purified protein derivative (PPD) in Mantoux positive lymphocyte donors.

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References

    1. J Clin Pathol. 1962 Jul;15(4):367-73 - PubMed
    1. Proc Soc Exp Biol Med. 1950 May;74(1):106-8 - PubMed
    1. J Histochem Cytochem. 1965 Mar;13:155-60 - PubMed
    1. J Biol Chem. 1955 Jan;212(1):125-33 - PubMed
    1. Scand J Clin Lab Invest Suppl. 1968;97:77-89 - PubMed

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