Review
doi: 10.3109/10428199309047874.
Expression of human endogenous retrovirus (HERV-K) in chronic myeloid leukemia
Affiliations
- PMID: 7504541
- DOI: 10.3109/10428199309047874
Item in Clipboard
Review
Expression of human endogenous retrovirus (HERV-K) in chronic myeloid leukemia
Leuk Lymphoma.
1993.
Abstract
We have previously demonstrated the presence of a reverse transcriptase-like enzyme in retroviral particles from patients with essential thrombocythemia, polycythemia vera, and chronic myelogenous leukemia. It was subsequently shown that the human genome contains 50 copies of HERV-K. HERV-K is a human endogenous class I retroviral element that contains gag, pol, and env open reading frames. Using both reverse transcriptase-polymerase chain reaction and ribonuclease protection assays, it is demonstrated that the HERV-K pol is expressed in human blood leukocytes. The data indicates that this expression is restricted in CML white cells and is the result of gene regulation.
Similar articles
-
Two groups of endogenous MMTV related retroviral env transcripts expressed in human tissues.Virus Genes. 1997;15(2):123-33. doi: 10.1023/a:1007910924177. Virus Genes. 1997. PMID: 9421877
-
Expression of HERV-K proviruses in human leukocytes.Blood. 1993 May 1;81(9):2369-74. Blood. 1993. PMID: 7683217
-
Molecular biology of type A endogenous retrovirus.Kitasato Arch Exp Med. 1990 Sep;63(2-3):77-90. Kitasato Arch Exp Med. 1990. PMID: 1710682 Review.
-
Evidence for copurification of HERV-K-related transcripts and a reverse transcriptase activity in human platelets from patients with essential thrombocythemia.Blood. 1997 Nov 15;90(10):4022-30. Blood. 1997. PMID: 9354671
-
HERV-K: the biologically most active human endogenous retrovirus family.J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13 Suppl 1:S261-7. doi: 10.1097/00042560-199600001-00039. J Acquir Immune Defic Syndr Hum Retrovirol. 1996. PMID: 8797733 Review.
Cited by
-
Two groups of endogenous MMTV related retroviral env transcripts expressed in human tissues.Virus Genes. 1997;15(2):123-33. doi: 10.1023/a:1007910924177. Virus Genes. 1997. PMID: 9421877
-
The promoter activity of long terminal repeats of the HERV-H family of human retrovirus-like elements is critically dependent on Sp1 family proteins interacting with a GC/GT box located immediately 3' to the TATA box.J Virol. 1996 Jan;70(1):188-98. doi: 10.1128/JVI.70.1.188-198.1996. J Virol. 1996. PMID: 8523525 Free PMC article.
-
Elevated HERV-K Expression in Soft Tissue Sarcoma Is Associated with Worsened Relapse-Free Survival.Front Microbiol. 2018 Feb 13;9:211. doi: 10.3389/fmicb.2018.00211. eCollection 2018. Front Microbiol. 2018. PMID: 29487589 Free PMC article.
-
Germ cell expression of an isolated human endogenous retroviral long terminal repeat of the HERV-K/HTDV family in transgenic mice.J Virol. 1999 Dec;73(12):9976-83. doi: 10.1128/JVI.73.12.9976-9983.1999. J Virol. 1999. PMID: 10559311 Free PMC article.
-
Distribution of human endogenous retrovirus HERV-K genomes in humans and different primates.Hum Genet. 1995 Aug;96(2):188-92. doi: 10.1007/BF00207377. Hum Genet. 1995. PMID: 7635468
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
