Review
doi: 10.1016/0955-0674(93)90141-c.
Stratification of the channel domain in neurotransmitter receptors
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- PMID: 7504932
- DOI: 10.1016/0955-0674(93)90141-c
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Review
Stratification of the channel domain in neurotransmitter receptors
Curr Opin Cell Biol.
1993 Aug.
Abstract
Analyses of the ionic pore of ligand-gated ion channels at the amino acid level reveal a structural and functional stratification of the M2 channel domain. Mutations in the equatorial and outer regions affect channel gating, whereas mutations of other amino acid rings alter ionic permeability or selectivity.
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