Modelling the cell-mediated immunity in homograft refection
- PMID: 750500
- DOI: 10.1016/0020-7101(78)90041-7
Modelling the cell-mediated immunity in homograft refection
Abstract
Lymphocytes which become sensitised at the periphery travel to the regional lymph nodes where they initiate an immunological response by increasing the production of immuno-competent lymphocytes. These lymphocytes migrate into the tissues via the blood stream and bring about the destruction of target cells. These notions, in the present analysis, are translated into a simple mathematical model. The model specifically considers the lymphocyte memory and increased secondary response.