The retron: a bacterial retroelement required for the synthesis of msDNA
- PMID: 7506087
- DOI: 10.1016/s0959-437x(05)80088-7
The retron: a bacterial retroelement required for the synthesis of msDNA
Abstract
'Retrons' are bacterial retroelements responsible for the synthesis of msDNA, a hybrid nucleic acid consisting of a single-stranded DNA that is branched out from an internal guanosine of an RNA molecule via a 2',5'-phosphodiester linkage. Retrons are found in a minor population of various bacterial species and are extensively diverse. Two important questions now demanding attention are whether retrons are mobile elements and why are they so diverse?
Similar articles
-
msDNA of bacteria.Prog Nucleic Acid Res Mol Biol. 1991;40:1-24. doi: 10.1016/s0079-6603(08)60838-7. Prog Nucleic Acid Res Mol Biol. 1991. PMID: 1709507 Review.
-
Retron-Ec107 is inserted into the Escherichia coli genome by replacing a palindromic 34bp intergenic sequence.Mol Microbiol. 1992 Feb;6(3):345-54. doi: 10.1111/j.1365-2958.1992.tb01477.x. Mol Microbiol. 1992. PMID: 1372675
-
Structure and biosynthesis of unbranched multicopy single-stranded DNA by reverse transcriptase in a clinical Escherichia coli isolate.Mol Microbiol. 1992 Dec;6(23):3531-42. doi: 10.1111/j.1365-2958.1992.tb01788.x. Mol Microbiol. 1992. PMID: 1282191
-
Reverse transcriptases from bacterial retrons require specific secondary structures at the 5'-end of the template for the cDNA priming reaction.J Biol Chem. 1993 Feb 5;268(4):2684-92. J Biol Chem. 1993. PMID: 7679101
-
Multi-copy single-stranded DNA in Escherichia coli.Microbiology (Reading). 2017 Dec;163(12):1735-1739. doi: 10.1099/mic.0.000563. Epub 2017 Oct 31. Microbiology (Reading). 2017. PMID: 29087272 Review.
Cited by
-
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10027-32. doi: 10.1073/pnas.96.18.10027. Proc Natl Acad Sci U S A. 1999. PMID: 10468556 Free PMC article.
-
Multicopy suppressors of the cold-sensitive phenotype of the pcsA68 (dinD68) mutation in Escherichia coli.J Bacteriol. 1996 Jul;178(13):3854-9. doi: 10.1128/jb.178.13.3854-3859.1996. J Bacteriol. 1996. PMID: 8682790 Free PMC article.
-
The role of ribonuclease H in multicopy single-stranded DNA synthesis in retron-Ec73 and retron-Ec107 of Escherichia coli.J Bacteriol. 1995 Jan;177(1):264-7. doi: 10.1128/jb.177.1.264-267.1995. J Bacteriol. 1995. PMID: 7528202 Free PMC article.
-
Cryo-EM structures of Escherichia coli Ec86 retron complexes reveal architecture and defence mechanism.Nat Microbiol. 2022 Sep;7(9):1480-1489. doi: 10.1038/s41564-022-01197-7. Epub 2022 Aug 18. Nat Microbiol. 2022. PMID: 35982312
-
High-efficiency retron-mediated single-stranded DNA production in plants.Synth Biol (Oxf). 2022 Nov 1;7(1):ysac025. doi: 10.1093/synbio/ysac025. eCollection 2022. Synth Biol (Oxf). 2022. PMID: 36452068 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources