Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Jan;144(1):51-9.

Vascular origin of Kaposi's sarcoma. Expression of leukocyte adhesion molecule-1, thrombomodulin, and tissue factor

Y M Zhang  1 , S Bachmann, C Hemmer, J van Lunzen, A von Stemm, P Kern, M Dietrich, R Ziegler, R Waldherr, P P Nawroth
Affiliations

Vascular origin of Kaposi's sarcoma. Expression of leukocyte adhesion molecule-1, thrombomodulin, and tissue factor

Y M Zhang et al. Am J Pathol. 1994 Jan.

Abstract

We studied seven cases of Kaposi's sarcomas (KS) obtained from patients with AIDS and one KS from a patient without HIV infection. Antigen expression was studied by immunocytochemistry and mRNA expression by in situ hybridisation. The markers tested were endothelial leukocyte adhesion molecule-1, thrombomodulin, and tissue factor. In all tumors (AIDS and non-AIDS associated) these markers reacted positive, indicating transcription and translation of these genes in KS. The synthesis and expression of tissue factor and thrombomodulin suggests that KS is a tumor that has tissue factor-mediated thrombin formation under the control of thrombomodulin. The expression of thrombomodulin and endothelial leukocyte adhesion molecule-1 provides evidence for the vascular origin of KS.

PubMed Disclaimer

References

    1. Am J Dermatopathol. 1979 Summer;1(2):165-72 - PubMed
    1. J Pathol. 1990 Jul;161(3):267-71 - PubMed
    1. J Cell Biol. 1985 Aug;101(2):363-71 - PubMed
    1. J Clin Invest. 1985 Nov;76(5):2003-11 - PubMed
    1. J Exp Med. 1986 Mar 1;163(3):740-5 - PubMed

Publication types

LinkOut - more resources