Review
doi: 10.1016/0952-7915(93)90113-7.
Role of CD40-CD40-ligand interaction in Ig-isotype switching
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- PMID: 7507684
- DOI: 10.1016/0952-7915(93)90113-7
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Review
Role of CD40-CD40-ligand interaction in Ig-isotype switching
Curr Opin Immunol.
1993 Dec.
Abstract
Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.
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