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Review
. 1993 Dec;5(6):963-7.
doi: 10.1016/0952-7915(93)90113-7.

Role of CD40-CD40-ligand interaction in Ig-isotype switching

R Fuleihan  1 , N Ramesh, R S Geha
Affiliations
Review

Role of CD40-CD40-ligand interaction in Ig-isotype switching

R Fuleihan et al. Curr Opin Immunol. 1993 Dec.

Abstract

Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.

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