Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Dec;2(12):2028-36.
doi: 10.1002/pro.5560021204.

Thermodynamics of BPTI folding

G I Makhatadze  1 , K S Kim, C Woodward, P L Privalov
Affiliations

Thermodynamics of BPTI folding

G I Makhatadze et al. Protein Sci. 1993 Dec.

Abstract

A calorimetric study of the basic pancreatic trypsin inhibitor (BPTI) has been performed using the new generation of the adiabatic scanning microcalorimeters, operating in an extended temperature range of 5-130 degrees C. Precise measurements of the heat capacities of the native and unfolded states of BPTI show that the heat capacity change upon unfolding strongly depends on temperature; its value is maximal at about 50 degrees C and diminishes as the temperature is increased. The temperature dependencies of the enthalpy and entropy changes upon BPTI unfolding were found to be similar to those normally observed for other small globular proteins. The stability of BPTI has been correlated with its structure.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Biopolymers. 1971;10(7):1243-51 - PubMed
    1. J Biol Chem. 1988 May 5;263(13):6001-4 - PubMed
    1. J Mol Biol. 1974 Jul 5;86(3):665-84 - PubMed
    1. J Mol Biol. 1976 Jul 25;105(1):1-12 - PubMed
    1. J Mol Biol. 1977 May 25;112(3):535-42 - PubMed

Publication types

LinkOut - more resources