Is urodilatin (rather than atriopeptin) the primary natriuretic peptide of the ANP family?

Abstract

This article summarizes evidence supporting the hypothesis that urodilatin, rather than atriopeptin, is the member of the atrial natriuretic peptide family primarily involved in the regulation of renal sodium excretion. A number of lines of evidence imply that atriopeptin is only of trivial importance in the regulation of sodium excretion during normal living conditions. On the other hand, urodilatin, which is produced in the kidneys, has properties very similar to atriopeptin. Moreover, its excretion in the urine appears to correlate quite closely with the concomitant excretion of sodium.