Review
doi: 10.1016/0027-5107(94)90124-4.
International Commission for Protection Against Environmental Mutagens and Carcinogens. Approaches to SAR in carcinogenesis and mutagenesis. Prediction of carcinogenicity/mutagenicity using MULTI-CASE
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- PMID: 7508546
- DOI: 10.1016/0027-5107(94)90124-4
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Review
International Commission for Protection Against Environmental Mutagens and Carcinogens. Approaches to SAR in carcinogenesis and mutagenesis. Prediction of carcinogenicity/mutagenicity using MULTI-CASE
Mutat Res.
.
Abstract
The assumptions and considerations underlying the use of structure-activity studies in the field of genotoxicity are discussed and reviewed. The MULTI-CASE program, recently introduced as a second generation CASE program is described and its special features highlighted. Some of the problems relevant to the use of structure-activity tools are also discussed. A list of these problems is as follows: Problems with non-congeneric data bases, Problems with expert systems, Problems with the size of the data bases, Problems with "structural alerts", Problems with QSAR, Problems with Metabolic transformations, and Problems with short-term assays.
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