Comparative Study
Effects of low doses of aprotinin on clotting times activated with celite and kaolin
Affiliations
- PMID: 7508668
Item in Clipboard
Comparative Study
Effects of low doses of aprotinin on clotting times activated with celite and kaolin
Acta Anaesthesiol Belg.
1993.
Abstract
The effects of aprotinin (2 x 10(6) and 4 x 10(6) PIU Iniprol) on the activated clotting time (ACT) with both celite- and kaolin-activated tubes were investigated in 52 patients, scheduled for elective coronary artery bypass grafting. Two whole blood samples (2 ml sample volume) were tested simultaneously with Hemochron automated timing systems at different intervals before, during and after cardiopulmonary bypass. At none of the times of measurement there was a difference in ACT measured with celite or with kaolin as coagulation activator. It is concluded that when aprotinin is used in this low dose regimen, celite- and kaolin-activated tubes are equally reliable for monitoring ACT.
Similar articles
-
In vitro effects of aprotinin on activated clotting time measured with different activators.J Thorac Cardiovasc Surg. 1992 Oct;104(4):1135-40. J Thorac Cardiovasc Surg. 1992. PMID: 1383640
-
Celite and kaolin produce differing activated clotting times during cardiopulmonary bypass under aprotinin therapy.Thorac Cardiovasc Surg. 1994 Aug;42(4):218-21. doi: 10.1055/s-2007-1016491. Thorac Cardiovasc Surg. 1994. PMID: 7529949
-
Aprotinin does not prolong the Sonoclot aprotinin-insensitive activated clotting time.J Clin Anesth. 2007 Sep;19(6):424-8. doi: 10.1016/j.jclinane.2007.03.003. J Clin Anesth. 2007. PMID: 17967670
-
Safety issues in heparin and protamine administration for extracorporeal circulation.J Cardiothorac Vasc Anesth. 1998 Apr;12(2 Suppl 1):17-20. J Cardiothorac Vasc Anesth. 1998. PMID: 9583571 Review.
-
Anticoagulation and anticoagulation reversal with cardiac surgery involving cardiopulmonary bypass: an update.J Cardiothorac Vasc Anesth. 1999 Aug;13(4 Suppl 1):18-29; discussion 36-7. J Cardiothorac Vasc Anesth. 1999. PMID: 10468245 Review.
Cited by
-
Aprotinin. A review of its pharmacology and therapeutic efficacy in reducing blood loss associated with cardiac surgery.Drugs. 1995 Jun;49(6):954-83. doi: 10.2165/00003495-199549060-00008. Drugs. 1995. PMID: 7543841 Review.