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. 1994 Jan;85(1):32-9.
doi: 10.1111/j.1349-7006.1994.tb02883.x.

Abundant but inactive-state gp140proto-trk is expressed in neuroblastomas of patients with good prognosis

H Iwata  1 , T Ito, T Mutoh, Y Ishiguro, H Xiao, M Hamaguchi
Affiliations

Abundant but inactive-state gp140proto-trk is expressed in neuroblastomas of patients with good prognosis

H Iwata et al. Jpn J Cancer Res. 1994 Jan.

Abstract

Steady-state levels of gp140proto-trk in cell lines and tumor tissues of neuroblastoma were examined by immunoblotting with anti-gp140proto-trk. The level of gp140proto-trk varied but showed good correlations with the stage of the tumor and the age of the patients at the time of diagnosis. Moreover, patients with higher expression of gp140proto-trk clearly had a far better survival rate than those with lower expression, suggesting that suppression of gp140proto-trk strongly correlates with the malignant conversion of the tumor. However, we found that neither autophosphorylation of gp140proto-trk nor tyrosine phosphorylation of cellular proteins was elevated in tumors of the higher expression group. These results suggest that gp140proto-trk does not actively participate in the process of transformation or the suppression of malignant conversion. Rather, the higher level of gp140proto-trk may reflect the greater level of differentiation of tumor cells.

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