doi: 10.1128/JVI.68.3.1970-1971.1994.
Redesignation of the RNase D activity associated with retroviral reverse transcriptase as RNase H
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- PMID: 7509004
- PMCID: PMC236660
- DOI: 10.1128/JVI.68.3.1970-1971.1994
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Redesignation of the RNase D activity associated with retroviral reverse transcriptase as RNase H
J Virol.
1994 Mar.
Abstract
In the presence of Mn2+, reverse transcriptase of both human immunodeficiency virus and murine leukemia virus hydrolyzes duplex RNA. However, designating this novel activity RNase D conflicts with Escherichia coli RNase D, which participates in tRNA processing. On the basis of its location in the RNase H domain, we propose that this novel retroviral activity be redesignated RNase H*.
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