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. 1994 Mar;68(3):1970-1.
doi: 10.1128/JVI.68.3.1970-1971.1994.

Redesignation of the RNase D activity associated with retroviral reverse transcriptase as RNase H

Z Hostomsky  1 , S H Hughes, S P Goff, S F Le Grice
Affiliations

Redesignation of the RNase D activity associated with retroviral reverse transcriptase as RNase H

Z Hostomsky et al. J Virol. 1994 Mar.

Abstract

In the presence of Mn2+, reverse transcriptase of both human immunodeficiency virus and murine leukemia virus hydrolyzes duplex RNA. However, designating this novel activity RNase D conflicts with Escherichia coli RNase D, which participates in tRNA processing. On the basis of its location in the RNase H domain, we propose that this novel retroviral activity be redesignated RNase H*.

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