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. 1994 Jan:75 ( Pt 1):157-64.
doi: 10.1099/0022-1317-75-1-157.

Immune response to human papillomavirus type 16 E6 gene in a live vaccinia vector

L Gao  1 , B Chain, C Sinclair, L Crawford, J Zhou, J Morris, X Zhu, H Stauss
Affiliations

Immune response to human papillomavirus type 16 E6 gene in a live vaccinia vector

L Gao et al. J Gen Virol. 1994 Jan.

Abstract

Immunization of mice with a recombinant vaccinia virus expressing the human papillomavirus type 16 (HPV-16) E6 gene elicits specific antibody, proliferative and cytotoxic T lymphocyte responses. T and B cell epitopes were mapped by using synthetic peptides. This study provides the background to future investigation aimed at developing prophylactic and therapeutic vaccines against HPV-16 infection and cervical cancer.

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