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Case Reports
. 1993 Dec;7(6):735-6.
doi: 10.1007/BF01213337.

Renal tubular acidosis preceding systemic lupus erythematosus

A Bagga  1 , Y Jain, R N Srivastava, U N Bhuyan
Affiliations
Case Reports

Renal tubular acidosis preceding systemic lupus erythematosus

A Bagga et al. Pediatr Nephrol. 1993 Dec.

Abstract

A 10-year-old girl with distal renal tubular acidosis (RTA) for 4 years (adequately treated for 3 years) developed clinical features suggesting systemic lupus erythematosus (SLE) with supportive laboratory evidence. She had heavy proteinuria and a decreased creatinine clearance (CCr). Renal biopsy showed diffuse proliferative and sclerosing glomerulonephritis with severe tubulointerstitial changes. Following treatment with corticosteroids and cyclophosphamide, she had a clinical remission, an increase in CCr and recovery from systemic acidosis. It is likely that distal RTA in this patient was a manifestation of SLE.

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