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. 1993 Dec;425(5-6):511-7.
doi: 10.1007/BF00374879.

Calcium permeability of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells

Z Zhou  1 , E Neher
Affiliations

Calcium permeability of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells

Z Zhou et al. Pflugers Arch. 1993 Dec.

Abstract

The fractional contribution of Ca to current flow through neuronal-type nicotinic acetylcholine receptor channels was determined by quantitative fluorescence microfluorimetry using fura-2. The method, which has been applied already to several types of cells and channels is described in detail here. At -70 mV and 2 mM external Ca concentration it was found that Ca contributes 2.5% to the net current. The fractional contribution was found to be voltage dependent, increasing at negative potentials e-fold for a 110 mV potential difference. Total non-specific cation current was found to have a bell-shaped dependence on external Ca concentration peaking at 2 mM.

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