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. 1994 Apr 29;264(5159):716-9.
doi: 10.1126/science.7513441.

Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines

A L Cox  1 , J Skipper, Y Chen, R A Henderson, T L Darrow, J Shabanowitz, V H Engelhard, D F Hunt, C L Slingluff Jr
Affiliations

Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines

A L Cox et al. Science. .

Abstract

Of several thousand peptides presented by the major histocompatibility molecule HLA-A2.1, at least nine are recognized by melanoma-specific cytotoxic T lymphocytes (CTLs). Tandem mass spectrometry was used to identify and to sequence one of these peptide epitopes. Melanoma-specific CTLs had an exceptionally high affinity for this nine-residue peptide, which reconstituted an epitope for CTL lines from each of five different melanoma patients tested. Recognition by multiple CTL lines suggests that this may be a promising candidate for use in peptide-based melanoma vaccines.

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