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Review
. 1994 Feb;4(1):70-7.
doi: 10.1016/0959-4388(94)90034-5.

Action potentials, calcium transients and the control of differentiation of excitable cells

N C Spitzer  1 , X Gu, E Olson
Affiliations
Review

Action potentials, calcium transients and the control of differentiation of excitable cells

N C Spitzer et al. Curr Opin Neurobiol. 1994 Feb.

Abstract

Calcium influx via action potentials in differentiating nerve and muscle is regulated principally by the expression of potassium currents. Transient elevations of intracellular calcium in spontaneously active cells are necessary for normal neuronal development. The mechanisms that connect calcium elevations to long term developmental change are likely to be utilized in the mature nervous system.

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