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. 1994 Mar 7;639(1):171-4.
doi: 10.1016/0006-8993(94)91779-5.

Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis

H Akiyama  1 , T Nishimura, H Kondo, K Ikeda, Y Hayashi, P L McGeer
Affiliations

Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis

H Akiyama et al. Brain Res. .

Abstract

The receptor for macrophage colony stimulating factor (CSF-1) was localized immunohistochemically in postmortem human brain tissue. Microglia constitutively expressed the receptor for CSF-1 and its expression was upregulated in lesions of Alzheimer's disease and amyotrophic lateral sclerosis. The CSF-1 mediated pathway appears to be involved in the response and activation of microglia in the central nervous system lesions.

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