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. 1994 Jun;69(6):1160-5.
doi: 10.1038/bjc.1994.228.

Relationship of transforming growth factor beta 1 to extracellular matrix and stromal infiltrates in invasive breast carcinoma

R A Walker  1 , S J Dearing, B Gallacher
Affiliations
Free PMC article

Relationship of transforming growth factor beta 1 to extracellular matrix and stromal infiltrates in invasive breast carcinoma

R A Walker et al. Br J Cancer. 1994 Jun.
Free PMC article

Abstract

Transforming growth factor beta (TGF-beta) comprises a group of multifunctional regulatory proteins, whose effects include stimulation of extracellular matrix formation and modification of immune function. The presence of TGF-beta 1 and TGF-beta 2 in invasive breast carcinomas has been determined and related to pathological features, the presence of fibronectin and tenascin and lymphocyte/macrophage infiltration, using immunohistochemistry. Differences were observed in the extent of reactivity within the same carcinoma and between tumours stained with an antibody detecting TGF-beta 1 ane one detecting TGF-beta plus TGF-beta 2, the latter having a higher level of reactivity. Prominent reactivity for TGF-beta 1 was associated with lymph node metastasis, (0.02 > P > 0.01), increased detection of cellular fibronectin, fine stromal fibronectin staining, more prominent reactivity for tenascin (0.02 > P > 0.01), the presence of tumour-associated macrophage infiltration and altered ratios of CD4 and CD8 lymphocyte populations, with CD8 lymphocytes predominating. These associations were not observed for carcinomas showing prominent staining with antibody detecting TGF-beta 2 as well as TGF-beta 1. The findings indicate that TGF-beta 1 may have a role in invasion and metastasis of breast carcinomas.

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References

    1. Semin Hematol. 1985 Jan;22(1):27-40 - PubMed
    1. Cancer Res. 1993 Jan 1;53(1):183-90 - PubMed
    1. Virchows Arch A Pathol Anat Histopathol. 1985;407(3):337-46 - PubMed
    1. J Biol Chem. 1986 Mar 25;261(9):4337-45 - PubMed
    1. J Exp Med. 1986 May 1;163(5):1037-50 - PubMed

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