Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Apr;85(4):331-4.
doi: 10.1111/j.1349-7006.1994.tb02362.x.

Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor

H Maeda  1 , Y Noguchi, K Sato, T Akaike
Affiliations

Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor

H Maeda et al. Jpn J Cancer Res. 1994 Apr.

Abstract

A newly discovered nitric oxide radical scavenger, an imidazolineoxyl N-oxide derivative, was used to investigate the role of nitric oxide radical (.NO) in the vascular permeability enhancement of solid tumor. Sarcoma-180 solid tumor in ddY mice was used for this experiment. Electron spin resonance spectroscopy was used to quantitate the reacted and unreacted scavenger. The results showed that extensive extravasation, assessed by intravenous injection of Evans blue, could be greatly suppressed by both .NO scavenger administered orally and .NO synthase inhibitor administrated intraperitoneally. This indicates that .NO is responsible for the vascular permeability in solid tumors.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. ) Akaike , T. , Yoshida , M. , Miyamoto , Y. , Sato , K. , Kohno , M. , Sasamoto , K. , Miyazaki , K. , Ueda , S. and Maeda , H.Antagonistic action of imidazolineoxyl N‐oxides against endothelium‐derived relaxing factor/⋅NO through a radical reaction . Biochemistry , 32 , 827 – 832 ( 1993. ). - PubMed
    1. ) Akaike , T. , Yoshida , M. , Sato , K. , Ueda , S. and Meada , H.Therapeutic effect of a new ⋅NO‐antidote, imidazolineoxyl N‐oxide on endotoxin shock in rats . Proc. 3rd Int. Meet. on Biol. Nitric Oxide ( 1994. ), in press . - PubMed
    1. ) Maeda , H. , Akaike , T. , Yoshida , M. , Sato , K. and Noguchi , Y.A new class of antidote of nitric oxide, imidazolineoxyl N‐oxide derivative: therapeutic effect of endotoxin shock and suppressive effect on vascular permeability in solid tumor . In “ The Role of Nitric Oxide in Physiology and Pathology ,” ed. Koprowski H. , Springer‐Verlag; , Berlin ( 1994. ), in press .
    1. ) Folkman , J.What is the evidence that tumors are angiogenesis dependent ? J. Natl. Cancer Inst. , 82 , 4 – 6 ( 1990. ). - PubMed
    1. ) Skinner , S. A. , Tutton , P. J. M. and O'Brein , P. E.Microvascular architecture of experimental colon tumors in the rats . Cancer Res. , 50 , 2411 – 2417 ( 1990. ). - PubMed

Publication types

LinkOut - more resources