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Clinical Trial
. 1994:47 Suppl 1:39-43.
doi: 10.2165/00003495-199400471-00007.

Acute effects of tramadol in methadone-maintained volunteers

J Camí  1 , X Lamas, M Farré
Affiliations
Clinical Trial

Acute effects of tramadol in methadone-maintained volunteers

J Camí et al. Drugs. 1994.

Abstract

The opioid agonist and antagonist properties of tramadol were assessed in 6 male opioid-dependent volunteers enrolled in a methadone maintenance programme. Subjects participated in 3 experimental sessions in which the effects of intramuscular tramadol 100 and 300 mg and placebo were evaluated. Tramadol neither produced morphine-like effects nor precipitated a withdrawal syndrome; its subjective, behavioural and physiological effects were not different from those of placebo. Although the results of this study suggest that tramadol has a low abuse liability in opioid-dependent subjects, higher doses should be tested to confirm these data.

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