Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Jul 15;301 ( Pt 2)(Pt 2):313-6.
doi: 10.1042/bj3010313.

Uptake of nitric oxide synthase inhibitors by macrophage RAW 264.7 cells

K Schmidt  1 , P Klatt, B Mayer
Affiliations

Uptake of nitric oxide synthase inhibitors by macrophage RAW 264.7 cells

K Schmidt et al. Biochem J. .

Abstract

Uptake of the nitric oxide synthase inhibitors NG-methyl-L-arginine (L-NMA) and NG-nitro-L-arginine (L-NNA) by macrophages is mediated by two different mechanisms. Activation of the cells with cytokines resulted in an up-regulation of L-NMA uptake but did not affect L-NNA transport. Characterization of the transport sites revealed that uptake of L-NMA is mediated by a cationic amino acid transporter (system y+) whereas a neutral amino acid transporter (system L) accounts for the uptake of L-NNA.

PubMed Disclaimer

References

    1. Biochemistry. 1993 Sep 21;32(37):9677-85 - PubMed
    1. J Cell Physiol. 1993 Sep;156(3):626-34 - PubMed
    1. Br J Pharmacol. 1993 Dec;110(4):1401-6 - PubMed
    1. Mol Pharmacol. 1993 Sep;44(3):615-21 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1982 Oct;321(1):11-9 - PubMed

Publication types

MeSH terms