[Enzymologic factors in the development of ulcerative process in gastroduodenal mucosa]

Abstract

The contribution of gastric proteolytic enzymes to formation of an ulcerated defect in the mucosa of the stomach and duodenum was studied in the experimental and clinical settings. There is no evidence for involvement of gastric secretory proteinases (pepsins) in ulceration in early periods. The secretory enzymes are likely to participate in maintaining the existing ulcers, preventing their healing. In patients with ulcerative disease and in animals with experimental ulcers, gastric juice is more aggressive against the mucosa than that of healthy human beings and animals. A possible role of carbohydrate components of gastric juice in the regulation of the "aggression" of gastric enzymes, as well as that of lysosomal enzymes in ulceration, namely the forming role of the latter during early ulceration are considered in the paper.