Neuropeptides and interleukin-6 in human joint inflammation relationship between intraarticular substance P and interleukin-6 concentrations
- PMID: 7520139
- DOI: 10.1016/0304-3940(94)90331-x
Neuropeptides and interleukin-6 in human joint inflammation relationship between intraarticular substance P and interleukin-6 concentrations
Abstract
Plasma and synovial fluid concentrations of interleukin-6 (IL-6), using an enzyme-linked immunosorbent assay, as well as immunoreactive levels of calcitonin gene-related peptide (CGRP), substance P and vasoactive intestinal peptide (VIP) were measured in 18 patients with rheumatoid arthritis and 20 with osteoarthritis of the knee. The concentrations of IL-6 were elevated in both plasma and synovial fluids from patients with rheumatoid arthritis whereas higher levels of substance P-, CGRP- and VIP-like immunoreactivities were found in the synovial fluid, but not in plasma, from patients with rheumatoid arthritis when compared with those in osteoarthritis. Furthermore, IL-6 and substance P levels in synovial fluid were significantly correlated both in rheumatoid arthritis and osteoarthritis patients. Our data seem to support the idea of an important role shared by neuropeptides and IL-6 in the pathogenesis of human inflammatory joint disease.
Similar articles
-
Calcitonin gene-related peptide II, substance P and vasoactive intestinal peptide in plasma and synovial fluid from patients with inflammatory joint disease.Br J Rheumatol. 1993 Jan;32(1):31-5. doi: 10.1093/rheumatology/32.1.31. Br J Rheumatol. 1993. PMID: 7678534
-
Concentration of substance P, neurokinin A, calcitonin gene-related peptide, neuropeptide Y and vasoactive intestinal polypeptide in synovial fluid from knee joints in patients suffering from rheumatoid arthritis.Scand J Rheumatol. 1991;20(5):326-35. doi: 10.3109/03009749109096808. Scand J Rheumatol. 1991. PMID: 1947895
-
Effect of calcitonin gene-related peptide, neuropeptide Y, substance P, and vasoactive intestinal peptide on interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha production by peripheral whole blood cells from rheumatoid arthritis and osteoarthritis patients.Regul Pept. 2003 Aug 15;115(1):19-24. doi: 10.1016/s0167-0115(03)00127-7. Regul Pept. 2003. PMID: 12873794
-
Peripheral Nerve Fibers and Their Neurotransmitters in Osteoarthritis Pathology.Int J Mol Sci. 2017 Apr 28;18(5):931. doi: 10.3390/ijms18050931. Int J Mol Sci. 2017. PMID: 28452955 Free PMC article. Review.
-
A possible role for saliva as a diagnostic fluid in patients with chronic pain.Semin Arthritis Rheum. 1998 Jun;27(6):348-59. doi: 10.1016/s0049-0172(98)80014-0. Semin Arthritis Rheum. 1998. PMID: 9662753 Review.
Cited by
-
[Pathogenesis of rheumatoid arthritis].Med Klin (Munich). 1997 Jun 15;92(6):347-53. doi: 10.1007/BF03044776. Med Klin (Munich). 1997. PMID: 9297067 Review. German.
-
Vanillic Acid Reduces Pain-Related Behavior in Knee Osteoarthritis Rats Through the Inhibition of NLRP3 Inflammasome-Related Synovitis.Front Pharmacol. 2021 Feb 15;11:599022. doi: 10.3389/fphar.2020.599022. eCollection 2020. Front Pharmacol. 2021. PMID: 33658936 Free PMC article.
-
Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis.Arthritis Res Ther. 2005;7(3):R416-26. doi: 10.1186/ar1503. Epub 2005 Feb 7. Arthritis Res Ther. 2005. PMID: 15899028 Free PMC article.
-
Calcitonin Gene-Related Peptide Systemic Effects: Embracing the Complexity of Its Biological Roles-A Narrative Review.Int J Mol Sci. 2023 Sep 12;24(18):13979. doi: 10.3390/ijms241813979. Int J Mol Sci. 2023. PMID: 37762283 Free PMC article. Review.
-
Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse.J Neuroinflammation. 2018 Dec 3;15(1):335. doi: 10.1186/s12974-018-1364-5. J Neuroinflammation. 2018. PMID: 30509328 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials