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Comparative Study
. 1993 Jan-Feb:(1):83-8.

[The determination of the antigenic determinant of protective monoclonal antibodies specific to the Francisella tularensis lipopolysaccharide]

[Article in Russian]
V S Khlebnikov, I R Golovlev, N V Tokhtamysheva, S F Averin, D P Kulevatskiĭ, G K Grechko, A A Averina, S S Vetchinin
  • PMID: 7520655
Comparative Study

[The determination of the antigenic determinant of protective monoclonal antibodies specific to the Francisella tularensis lipopolysaccharide]

[Article in Russian]
V S Khlebnikov et al. Zh Mikrobiol Epidemiol Immunobiol. 1993 Jan-Feb.

Abstract

F. tularensis lipopolysaccharide (LPS) was studied with the use of monoclonal antibodies (McAb) having protective properties. The binding site of these McAb (IgG2a) is localized on the O-chain of LPS. In contrast to LPS isolated from vaccine strain 15, LPS isolated from F. tularensis cells in the R-form has no O-chains and does not interact with McAb.

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