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. 1994 Sep 26;352(2):206-10.
doi: 10.1016/0014-5793(94)00955-4.

Involvement of the brain type of ryanodine receptor in T-cell proliferation

Y Hakamata  1 , S Nishimura, J Nakai, Y Nakashima, T Kita, K Imoto
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Free article

Involvement of the brain type of ryanodine receptor in T-cell proliferation

Y Hakamata et al. FEBS Lett. .
Free article

Abstract

Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.

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