Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Nov;62(11):5177-82.
doi: 10.1128/iai.62.11.5177-5182.1994.

Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro

G N Vespa  1 , F Q Cunha, J S Silva
Affiliations

Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro

G N Vespa et al. Infect Immun. 1994 Nov.

Abstract

This study was carried out to determine the role of reactive nitrogen intermediates in Trypanosoma cruzi infection. In vitro, splenocytes obtained during the acute phase of infection produced elevated amounts of nitric oxide (NO) that were correlated with the resistance or susceptibility of the animals. In vivo, the levels of NO2- plus NO3- in plasma during the later phase of infection were higher in C57BL/6 mice than in BALBL/c mice. The treatment of infected C57BL/6 mice with inhibitors of NO synthase increased parasitemia and mortality. Finally, we found that the NO donor drug S-nitroso-acetyl-penicillamine is able to kill trypomastigotes in vitro in the absence of any other cells, suggesting a direct NO-mediated killing of T. cruzi.

PubMed Disclaimer

References

    1. Biochem Biophys Res Commun. 1989 Nov 30;165(1):284-91 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Sep;84(18):6369-73 - PubMed
    1. J Exp Med. 1989 Dec 1;170(6):2081-95 - PubMed
    1. Eur J Immunol. 1991 Dec;21(12):3009-14 - PubMed
    1. J Parasitol. 1962 Apr;48:223-8 - PubMed

Publication types