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. 1994 Nov;70(5):799-803.
doi: 10.1038/bjc.1994.402.

Identification of glioma-associated antigen MUC 2-63 as CD44

P Romeijn  1 , R Lenthall, D Stavrou, D Melcher, H Ladyman, M A Ritter
Affiliations
Free PMC article

Identification of glioma-associated antigen MUC 2-63 as CD44

P Romeijn et al. Br J Cancer. 1994 Nov.
Free PMC article

Abstract

Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies using MUC 2-63 and the CD44 anti-framework antibody F10-44-2. Thus not only MUC 2-63 but also other anti-CD44 monoclonal antibodies should prove useful in imaging and, perhaps, therapy of brain tumours.

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