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Comparative Study
. 1994 Jun;33(3):567-74.

Expression of human prostatic acid phosphatase and prostate specific antigen genes in neoplastic and benign tissues

F S Sharief  1 , J L Mohler, Y Sharief, S S Li
Affiliations
  • PMID: 7524903
Comparative Study

Expression of human prostatic acid phosphatase and prostate specific antigen genes in neoplastic and benign tissues

F S Sharief et al. Biochem Mol Biol Int. 1994 Jun.

Abstract

Expression of human prostatic acid phosphatase (ACPP) and prostate specific antigen (PSA) genes in prostatic carcinoma (CAP) and benign prostatic hyperplasia (BPH) was investigated by northern blot analyses. The expressions of ACPP and PSA, as well as the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase-muscle (LDH-A), were elevated significantly in prostatic carcinoma when compared with the expressions of these genes in benign prostatic hyperplasia in the same patient. The expression of the actin gene in both neoplastic and benign hyperplasia remained the same.

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