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Clinical Trial
. 1994 Nov;37(11):1593-601.
doi: 10.1002/art.1780371106.

Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome

I J Russell  1 , M D Orr, B Littman, G A Vipraio, D Alboukrek, J E Michalek, Y Lopez, F MacKillip
Affiliations
Clinical Trial

Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome

I J Russell et al. Arthritis Rheum. 1994 Nov.

Abstract

Objective: To measure, and seek clinical correlates with, levels of substance P (SP) in the cerebrospinal fluid (CSF) of fibromyalgia syndrome (FMS) patients.

Methods: CSF from 32 FMS patients and 30 normal control subjects was tested for SP by radioimmunoassay. Clinical measures included tender point examination and standardized questionnaires.

Results: CSF SP levels were 3-fold higher in FMS patients than in normal controls (P < 0.001), but they correlated only weakly with tenderness found on examination.

Conclusion: SP is significantly elevated in FMS CSF, but other abnormalities must exist in FMS to more fully explain the symptoms.

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