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. 1995 Jan;69(1):517-22.
doi: 10.1128/JVI.69.1.517-522.1995.

Isolation of a monoclonal antibody which blocks vaccinia virus infection

W Chang  1 , J C Hsiao, C S Chung, C H Bair
Affiliations

Isolation of a monoclonal antibody which blocks vaccinia virus infection

W Chang et al. J Virol. 1995 Jan.

Abstract

We have isolated a monoclonal antibody, B2, that neutralizes vaccinia virus infection. B2 reacts with a trypsin-sensitive cell surface epitope. B2 does not neutralize infection of herpes simplex virus, suggesting that the B2-reactive epitope is specifically involved in vaccinia virus entry. A survey of 12 different cell lines reveals a correlation between B2 reactivity and susceptibility to vaccinia virus infection. In addition, B2 interferes with vaccinia virus adsorption to target cells. Taken together, the B2-reactive epitope is part of a receptor that appears important for vaccinia virus entry.

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