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. 1994 Aug 3;270(4):379-82.
doi: 10.1016/0926-6917(94)90017-5.

Septic shock: no correlation between plasma levels of nitric oxide metabolites and hypotension or lethality

C van den Berg  1 , J G van Amsterdam, A Bisschop, J J Piet, J Wemer, D J de Wildt
Affiliations

Septic shock: no correlation between plasma levels of nitric oxide metabolites and hypotension or lethality

C van den Berg et al. Eur J Pharmacol. .

Abstract

In the Wistar rat (Riv:TOX strain), Escherichia coli-derived lipopolysaccharide, up to 100 mg/kg, did not affect blood pressure. However, 6 h after administration of live E. coli or Staphylococcus aureus (a microorganism without lipopolysaccharide), both dosed at 12 x 10(9) colony forming units/kg, mean arterial blood pressure significantly decreased to 64% and 48% compared to control, respectively. In contrast to lipopolysaccharide, bacteria produced a dose-dependent lethality within 24 h. Live S. aureus increased plasma levels of nitric oxide metabolites (NOx) only four-fold, while both lipopolysaccharide and live E. coli approximately 20-fold. In conclusion, we demonstrated a lack of correlation between plasma NOx levels and hypotension or lethality.

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