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Review
. 1994 Sep;49(2):209-19.
doi: 10.1016/0166-0934(94)90045-0.

Strategies for mapping and imitating viral B-cell epitopes

J Cason  1
Affiliations
Review

Strategies for mapping and imitating viral B-cell epitopes

J Cason. J Virol Methods. 1994 Sep.

Abstract

Identification of viral B-cell epitopes is of importance in the selection of peptides for inclusion into subunit vaccines, the development of virus-specific serological tests and understanding the interaction of antibodies with viruses at a molecular level. B-cell epitopes can often be determined unequivocally by X-ray analyses of antibody-antigen complexes. This technique is, however, time-consuming and alternative strategies have now been developed for identifying epitopes. This article provides an overview of approaches which are currently available for mapping and imitating B-cell epitopes.

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