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. 1995 Feb;194(2):483-9.
doi: 10.1148/radiology.194.2.7529934.

Metabolic alterations in the neonate and infant brain during development: evaluation with proton MR spectroscopy

H Kimura  1 , Y Fujii, S Itoh, T Matsuda, T Iwasaki, M Maeda, Y Konishi, Y Ishii
Affiliations

Metabolic alterations in the neonate and infant brain during development: evaluation with proton MR spectroscopy

H Kimura et al. Radiology. 1995 Feb.

Abstract

Purpose: To evaluate the usefulness of hydrogen-1 magnetic resonance (MR) spectroscopy in the evaluation of the developing brain.

Materials and methods: Localized MR spectra were obtained with an echo time of 272 msec from the brain of 78 neonates and infants aged 1 week to 100 months. All patients were retrospectively classified into three groups on the basis of neurologic development: abnormal (group 2, n = 21), normal despite minor neurologic signs (group 1, n = 23), and normal (group 0, n = 34).

Results: Seventeen patients in group 2 and eight patients in group 1 revealed abnormally low N-acetylaspartate (NAA)/choline or NAA/creatine ratios compared with those obtained in group 0. MR spectroscopy was slightly more useful in the differentiation of patients in groups 2 and 1 (chi 2 test, P < .005) than MR imaging (P < .01).

Conclusion: H-1 MR spectroscopy provides prognostic information about the brain in healthy and neurologically damaged infants and augments the value of MR imaging.

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