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Review
. 1994 Oct;17(10):404-5.
doi: 10.1016/0166-2236(94)90013-2.

Synuclein proteins and Alzheimer's disease

A J Brookes  1 , D St Clair
Affiliations
Review

Synuclein proteins and Alzheimer's disease

A J Brookes et al. Trends Neurosci. 1994 Oct.

Abstract

In Alzheimer's disease, synuclein/NAC (non-amyloid beta component of Alzheimer's disease amyloid) proteins are found in presynaptic cholinergic nerve terminals that degenerate early in Alzheimer's disease, and they are also found closely linked to beta-amyloid fibrils in senile plaques. Synuclein/NAC proteins provide a potential molecular link between the degeneration of cholinergic nerve terminals, and the formation of plaques, and might have a primary role in their development.

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