Review
doi: 10.1016/s0960-5428(06)80253-6.
gp120 neurotoxicity in primary cortical cultures
Affiliations
- PMID: 7533039
- DOI: 10.1016/s0960-5428(06)80253-6
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Review
gp120 neurotoxicity in primary cortical cultures
Adv Neuroimmunol.
1994.
Abstract
The human immunodeficiency virus type 1 coat protein, gp120, kills neurons in a nitric oxide dependent manner in primary cortical cultures at low picomolar concentrations. gp120 neurotoxicity also requires calcium and glutamate and is blocked by glutamate receptor antagonists. In addition, superoxide anions play a role in gp120 neurotoxicity since superoxide dismutase also attenuates neurotoxicity.
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