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. 1976;4(2):107-9.
doi: 10.1007/BF01638726.

Interactions between aminoglycoside antibiotics and carbenicillin or ticarillin

H A Holt, J M Broughall, M McCarthy, D S Reeves

Interactions between aminoglycoside antibiotics and carbenicillin or ticarillin

H A Holt et al. Infection. 1976.

Abstract

Carbenicillin or ticarcillin were incubated individually with each of the following antibiotics: gentamicin, tobramycin, sisomicin, amikacin. The residual activity of each aminoglycoside in this mixture was assayed enzymatically. Amikacin was inactivated the least of the aminoglycosides. Both penicillins inactivated each aminoglycoside to a similar extent by a degree which varied according to the medium of incubaiton, the least inactivation being seen in pooled human serum and the most in phosphate buffer at pH 7.4.

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