Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1994 Dec;38(6):567-71.
doi: 10.1111/j.1365-2125.1994.tb04398.x.

Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA)

A K Gonschior  1 , U Christians, F Braun, M Winkler, A Linck, J Baumann, K F Sewing
Affiliations
Clinical Trial

Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA)

A K Gonschior et al. Br J Clin Pharmacol. 1994 Dec.

Abstract

1. Blood and urine concentrations of the macrolide immunosuppressant FK506 and its metabolites were measured in seven orthotopic liver transplant patients after the first oral dose of FK506 (0.04 +/- 0.02 mg kg-1) used as primary immunosuppressant. A specific h.p.l.c.-MS assay was used, allowing the measurement of parent drug and eight metabolites. Results were compared with those obtained using a microparticle enzyme immunoassay (MEIA). 2. Blood drug concentrations were described by an open two compartment model with first-order absorption giving the following mean data: tmax: 1.9 (h), Cmax: 17.4 (microgram l-1), AUC: 328.1 (microgram l-1 h), t1/2,1: 0.74 (h). The terminal elimination half-life was estimated at about 26 h using the h.p.l.c.-MS assay. 3. The metabolites found in blood were demethyl-FK506 and demethyl-hydroxy-FK506, while in urine FK506 and eight of its metabolites were detected.

PubMed Disclaimer

References

    1. Clin Pharmacokinet. 1986 Mar-Apr;11(2):107-32 - PubMed
    1. Drug Metab Dispos. 1993 Nov-Dec;21(6):971-7 - PubMed
    1. Lancet. 1989 Oct 28;2(8670):1000-4 - PubMed
    1. Transplant Proc. 1990 Feb;22(1):50-1 - PubMed
    1. Transplant Proc. 1990 Feb;22(1):57-9 - PubMed

Publication types