Review
Regulation and functions of nitric oxide in the liver in sepsis and inflammation
Affiliations
- PMID: 7535650
Item in Clipboard
Review
Regulation and functions of nitric oxide in the liver in sepsis and inflammation
New Horiz.
1995 Feb.
Abstract
The liver plays important roles in metabolic and immune responses during sepsis. It is the major site of acute-phase protein synthesis and is responsible for the clearance of circulating pathogens. In addition to mediators such as cytokines and eicosanoids, numerous studies have emphasized the role of nitric oxide (NO.) in influencing hepatic function during sepsis. The induction and the distribution of inducible nitric oxide synthase in the liver, the regulation of the enzyme, and the functions of NO. in the liver are the subject of this review.
Similar articles
-
[Metabolism and function of nitric oxide in the liver].Z Gastroenterol. 1994 Jan;32(1):24-30. Z Gastroenterol. 1994. PMID: 7511856 Review. German.
-
Hepatic nitric oxide production following acute endotoxemia in rats is mediated by increased inducible nitric oxide synthase gene expression.Hepatology. 1995 Jul;22(1):223-34. Hepatology. 1995. PMID: 7541386
-
Inflammation, immunoregulation, and inducible nitric oxide synthase.J Leukoc Biol. 1993 Aug;54(2):171-8. J Leukoc Biol. 1993. PMID: 7689630 Review.
-
Nitric oxide synthase expression is induced in hepatocytes in vivo during hepatic inflammation.J Surg Res. 1993 Oct;55(4):427-32. doi: 10.1006/jsre.1993.1164. J Surg Res. 1993. PMID: 7692140
-
Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia.J Leukoc Biol. 2002 Jun;71(6):1005-11. J Leukoc Biol. 2002. PMID: 12050186
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical