Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Apr;38(4):485-91.
doi: 10.1002/art.1780380405.

Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes

T Nakajima  1 , H Aono, T Hasunuma, K Yamamoto, T Shirai, K Hirohata, K Nishioka
Affiliations

Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes

T Nakajima et al. Arthritis Rheum. 1995 Apr.

Abstract

Objective: To determine whether apoptosis occurs in rheumatoid arthritis (RA) synoviocytes, and if this phenomenon is dependent on the Fas/Apo-1 pathway.

Methods: Apoptotic change in vivo was examined in RA synovial cells by several standard methods. The ability of cells to undergo Fas-induced apoptosis was determined in vitro.

Results: Typical apoptotic change was demonstrated in RA synovial cells by each method. Anti-Fas antibody induced apoptotic synovial cell death in vitro.

Conclusion: This is the first reported study to demonstrate apoptosis in RA synovial cells. The findings indicate that rheumatoid synoviocytes undergo Fas-mediated apoptosis.

PubMed Disclaimer

Publication types