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. 1995 May 12;268(5212):863-5.
doi: 10.1126/science.7538697.

CD1 recognition by mouse NK1+ T lymphocytes

A Bendelac  1 , O Lantz, M E Quimby, J W Yewdell, J R Bennink, R R Brutkiewicz
Affiliations

CD1 recognition by mouse NK1+ T lymphocytes

A Bendelac et al. Science. .

Abstract

Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of CD1-specific T cells selected during T cell development, or whether their recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific. This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells.

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