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Case Reports
. 1995 Mar;14(2):204-8.
doi: 10.1007/BF02214945.

Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash

M F McMullin  1 , M B Finch
Affiliations
Case Reports

Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash

M F McMullin et al. Clin Rheumatol. 1995 Mar.

Abstract

A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.

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